Download A Time for Metabolism and Hormones by Paolo Sassone-Corsi, Yves Christen PDF

By Paolo Sassone-Corsi, Yves Christen

Recent years have obvious wonderful advances within the box of circadian biology. those have attracted the curiosity of researchers in lots of fields, together with endocrinology, neurosciences, melanoma, and behaviour. by means of integrating a circadian view in the fields of endocrinology and metabolism, researchers can be capable of show many, yet-unsuspected elements of the way organisms do something about alterations within the surroundings and next keep an eye on of homeostasis. This box is starting new avenues in our knowing of metabolism and endocrinology. A panel of the main uncommon investigators within the box accrued jointly to debate the current kingdom and the way forward for the sphere. The editors belief that this quantity can be of use to these colleagues who should be identifying up the problem to resolve how the circadian clock may be certain for the long run improvement of particular pharmacological techniques towards a few pathologies.

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To determine if temporal separation of gene expression by the clock was important for metabolic physiology, we sought to disrupt this temporal relationship. Reasoning that the time of feeding might be important for the peak in metabolic gene expression, but perhaps not for expression of immune genes, we restricted food to a time of day when feeding was typically less (6 h in the early evening) and we examined circadian gene expression (Xu et al. 2011). We found that the time of feeding was indeed important, in fact even more than predicted.

In the absence of environmental cycles. Also, it is eliminated in the dark in flies lacking the Clk gene, demonstrating that it is under the control of the molecular clock mechanism described above (Xu et al. 2008). To address the regulation of the feeding rhythm, we considered a role for the fat body, as this is a major metabolic tissue in Drosophila and is generally considered the functional equivalent of the liver. We found that clock genes, specifically tim, were expressed in the fat body and displayed a daily rhythm (Xu et al.

Further, simply substituting regular with high fat chow in mice fed ad libitum lengthens Circadian Mechanisms in Bioenergetics and Cell Metabolism 29 periodicity of locomotor activity and alters peripheral metabolic rhythms, providing further evidence for a bidirectional relationship between clock function and metabolism (Kohsaka et al. 2007). Our discovery that diet-induced obesity reprograms both the cellular molecular clock and behavior revealed for the first time that a controlled change in nutritional environment leads to altered circadian rhythms.

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