By Philip M. Parker
In March 2001, the nationwide Institutes of wellbeing and fitness issued the subsequent caution: "The variety of sites providing health-related assets grows each day. Many websites supply worthy details, whereas others can have info that's unreliable or misleading." in addition, as a result swift bring up in Internet-based details, many hours could be wasted looking out, deciding upon, and printing. given that merely the smallest fraction of data facing Alzheimer ailment is listed in se's, comparable to www.google.com or others, a non-systematic method of net examine could be not just time eating, but additionally incomplete. This ebook used to be created for doctors, scholars, and contributors of most of the people who are looking to behavior scientific learn utilizing the main complex instruments on hand and spending the smallest amount of time doing so.
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Neurology; Indiana UnivPurdue Univ at Indianapolis 620 Union Drive, Room 618 Indianapolis, in 462025167 Timing: Fiscal Year 2004; Project Start 19-FEB-2001; Project End 31-JAN-2006 Summary: (Adapted From The Applicant's Abstract): The primary objective of this Mentored Patient-Oriented Research Career Development Award is to permit Rebecca M. Evans (the candidate) to develop her full potential as a clinical investigator in dementia research. Dr Evans has completed a 2-year fellowship in neurodegenerative disease and has initiated research into vascular aspects of dementia.
Our approach provides quantitative readouts of AD-specific oxidative stress to optimize an anti-oxidant treatment. While we have shown that oxidative stress results from the senile plaques of AD themselves, it is likely that other p species, such as small diffusible aggregates, oligomers, or Aa derived diffusible ligands (ADDLs) are also a source of reactive oxygen species. This grant application proposes to identify aggregated and soluble Aa components that are sources of oxidative stress, and evaluate anti-oxidant treatments for protective activity both in vitro and in vivo using transgenic mouse models of Alzheimer's disease.
As the average lifespan continues to increase, particularly in the Western world, AD represents one of the single greatest burdens on the healthcare system. This symposium will focus on genetic risk factors, relevant cellular pathways and emerging therapies for AD and frontal temporal dementia. ; Psychiatry; Mount Sinai School of Medicine of Nyu of New York University New York, Ny 10029 Timing: Fiscal Year 2004; Project Start 01-SEP-1998; Project End 31-AUG-2008 Summary: (provided by applicant): This is a continuation of a double blind placebo controlled multi-center clinical trial to determine if estrogen can delay the onset of Alzheimer's Disease (AD) and reduce memory decline.